Neuronal ceroid lipofuscinosis (NCL) is a group of inherited neurodegenerative disorders affecting children and adults. It is characterized by the buildup of lipofuscin in neurons, leading to progressive cognitive and motor decline. Symptoms of NCL typically begin in childhood and can include seizures, vision loss, and loss of motor skills. There are several subtypes of NCL, each caused by mutations in different genes. Currently, there is no cure for NCL, and treatment focuses on managing symptoms and improving quality of life for affected individuals. Research in this area aims to better understand the underlying causes of NCL and develop potential therapies to slow down or halt the progression of the disease.